 | Michael J. Fox Daniel |
 | Kirk Douglas Uncle Joe |
 | Nancy Travis Robin |
 | Olivia d'Abo Molly Richardson |
 | Phil Hartman Frank |
 | Ed Begley Jr. Carl |
 | Jere Burns Glen |
 | Colleen Camp Patti |
 | Bob Balaban Ed |
 | Joyce Hyser Muriel |
 | Mary Ellen Trainor Nora |
 | Siobhan Fallon Hogan Tina |
 | Kevin McCarthy Bartlett |
 | Khandi Alexander Laura |
 | Jonathan Lynn Douglas |
 | Francis X. McCarthy Daniel Sr. |
 | Tom Mason Actor |
 | Austin Pendleton Hotel Clerk |
 | Lowell Ganz TV Director |
 | Bea Soong Assistant TV Director |
 | Beau Byron Little Danny |
| Ronnie Prettyman Little Carl |
| Sean Babb Dennis |
 | Adam Hendershott Joe (9 years old) |
 | Eric Lloyd Joe (6 years old) |
 | Kirsten Dunst Jolene |
| Lisa Bradley Joette |
| Rita Gomez Yolanda |
| John Lafayette Wayne |
| Rich Baretta Beefy Worker |
| Vince Morton Uncle Vince at the Piano |
 | Chris Schenkel Chris Schenkel |
| Directing | |
| Jonathan Lynn | Director |
Production | |
| George Folsey Jr. | Executive Producer |
| David T. Friendly | Executive Producer |
| Brian Grazer | Producer |
Sound | |
| Randy Edelman | Original Music Composer |
Camera | |
| Gabriel Beristain | Director of Photography |
Editing | |
| Tony Lombardo | Editor |
Crew | |
| Charles Croughwell | Stunt Coordinator |
Art | |
| Victoria Paul | Production Design |
Writing | |
| Babaloo Mandel | Writer |
| Lowell Ganz | Writer |
Production | |
| Karen Rea | Casting |
Costume & Make-Up | |
| Shay Cunliffe | Costume Design |
